What we know about the crash so far
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Watch: Aerial footage shows train crash scene Two trains have collided in Spain just south of the capital Madrid on Wednesday morning.
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Rail operator Adif says the incident occurred between a Renfe train and another of the Iryo company, which covers the Madrid to Seville route.
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So far at least 68 people are confirmed to have died in the incident.
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Here is what we know about the crash so far.
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The two trains collided just after 09:00 (08:00 GMT) between municipalities Mora and Orgaz, and about 140km (100 miles) south of Madrid.
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The accident happened when a high-speed train travelling from Madrid to the south of the country collided with another train that was apparently stationary.
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The crash caused at least two carriages to fall down an embankment. Broadcaster RTVE, quoting the transport ministry, said a Renfe train rear-ended an Iryo train.
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Renfe is Spain's national state-owned railway company while Iryo is a private high-speed railway operator.
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All train traffic on this line has been stopped at stations along the route, Adif said.
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Renfe said services between Madrid, Ciudad Real and Andalusia remain suspended.
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A passenger on board one of the trains told local media there was a heavy impact about 40 minutes into the journey.
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Iryo said its train was "struck from behind" by a Renfe train "due to causes that are still unknown.
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Transport minister Oscar Puente has said a computer failure led to the initial halt of six moving trains, including the two trains that subsequently collided.
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"In the event of a system failure, the control centre takes over," he said, adding it was the control centre which decided to allow the trains to move again, without any speed restrictions.
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That decision, Puente said, was made "under inexplicable circumstances".
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It resulted in the Renfe train crashing into the Iryo train, which was stationary on the tracks further ahead. Bloodied, dazed and angry - how passengers' rail journey turned to disaster in Spain Follow live: At least 68 killed in Spanish high-speed train crash Aerial footage shows the extent of the damage and the emergency response More than 500 people were believed to be on board both trains.
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Esther Padilla, spokesperson for the government of Castilla-La Mancha region, told TVE that one of the trains - managed by the Iryo company - was carrying 146 passengers plus one baby, while the Renfe-managed train had 397 passengers on board.
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A former government minister was also among those reported missing.
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The Spanish Confederation of Business Organizations (CEOE) posted on X that, Fátima Báñez - who heads the organization's foundation - was on board one of the trains involved in the crash.
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The Castilla La Mancha regional government said 64 people are now confirmed to have died.
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Speaking separately to Spanish media, he warned the death toll could increase further.
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Eighty people are being treated for injuries, according to authorities, with 50 of the casualties said to be in a serious condition, and 15 more in a critical condition.
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Spanish Prime Minister Pedro Sánchez has said "the whole of Spain is grieving" and that "lives have been shattered, families have been torn apart".
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"The pain is immense," he said on a visit to the crash site.
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The government was "trying to determine what was the origin of this tragedy, of this terrible accident," he added.
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"We will get to the bottom of this, and if there has been any negligence, it will come to light.
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"If there have been failures in the security system, they will be addressed with the utmost firmness."
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Sánchez and other Spanish politicians have cancelled all public engagements on Wednesday, including campaigning for next month's parliamentary elections.
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Spain's royal family posted on X that it was "shocked and concerned" and expressed condolences for the relatives of the deceased and those affected by the crash.
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A spokesperson for the EU said the bloc was ready to help Spain if needed.
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A huge emergency response is under way with fire crews and helicopters at the scene.
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Hospitals in the area have suspended planned surgeries as they deal with an influx of patients from the crash, Spanish media have reported.
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A blood transfusion centre in Madrid has also appealed for "urgent" donations.
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In a post on X, Centro de Transfusión said it made the request "in the face of a possible sudden increase in care needs".
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It reported that facilities in Toledo, Ciudad Real and Alcázar de San Juan have cancelled procedures as casualties from the crash begin to arrive.
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This is the second high-speed rail tragedy in Spain this year.
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In January a high-speed train derailed in southern Spain, its rear carriages going into the path of a state-run Renfe train, claiming the lives of 46 people. Are you in the affected region?
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If it safe to do, get in touch.
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If it is safe to do so, you can also get in touch by following this link
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